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Ask a Rev Cycle Expert: Difference Between CPT® 82270 and HCPCS code G0328?


What is the difference between CPT® 82270 and HCPCS code G0328? They both have status indicator A and Medicare seems to accept both. We are unsure if perhaps G0328 should be set up as an override for Medicare, but why do that if 82270 is also acceptable to Medicare?


The difference between the two codes is the mechanism of action used to determine the results of the test. Healthcare Common Procedure Coding System (HCPCS) code G0328 Colorectal cancer screening; fecal occult blood test, immunoassay, 1-3 simultaneous would be used when an immunoassay technique is used to determine the presence of blood in the patient’s stool. This test uses an antibody that binds to the hemoglobin to detect blood.

Current Procedural Terminology (CPT®) code 82270 Blood, occult, by peroxidase activity (eg, guaiac), qualitative; feces, consecutive collected specimens with single determination, for colorectal neoplasm screening (ie, patient was provided 3 cards or single triple card for consecutive collection) is used when the technique used to detect blood in the stool is by peroxidase activity. The card(s) is coated with a chemical, such as guaiac, and a testing solution, such as hydrogen peroxide, is put on the sample. The guaiac causes the stool sample to change colors.

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